Office 365 Update Restarts my Apps in SCCM Pushing Office 365 C2R updates through SCCM 1610 causes Office applications to close unexpectedly on client PCs This is a known bug since the release of ConfigMgr CB 1610. and was resolved with Hotfix KB4010155 https://support.microsoft.com/en-us/help/4010155/update-rollup-for-system-center-configuration-manager-current-branch-v After you start installation of Office updates from Software Center, users do not receive a notification message to exit all open Office 365 applications. This behavior occurs even with the forceappshutdown=False switch in the Configuration.xml file for Office 365. Conclusion Install all hotfixes https://support.microsoft.com/help/4010155 https://support.microsoft.com/help/4016483